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2023
Relationship between reproductive and bone biomarkers and osteoarthritis in zoo asian (elephas maximus) and African (loxodonta africana) elephants. Daniella E Chusyd 1 2, Janine L Brown 3, Lilian Golzarri-Arroyo 4, Stephanie L Dickinson 4, Virginia B Kraus 5 6, Jessica Siegal-Willott 7, Timothy M Griffin 8 9 10, Janet L Huebner 6, Katie L Edwards 3, David B Allison 4, Steven N Austad 2 11 12. PMID: 36640083 DOI: 10.1638/2021-0080 [Abstract]
2021
Zhu S, Batushansky A, Jopkiewicz A, Makosa D, Humphries KM, Van Remmen H, Griffin TM. (2021) Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions. Cartilage. 2021 Feb 11:1947603521993209. doi: 10.1177/1947603521993209. [Abstract]
2020
Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, and Xia L. (2020) Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science. 370(6515):467-472. doi/org/10.1126/science.aay7367. [Abstract]
Sun C, Sakashita H, Kim J, Tang Z, Upchurch GM, Yao L, Berry WL, Griffin TM, Olson LE. (2020) Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis. Cell Stem Cell. 26(5):707-721.e5. doi.org/10.1016/j.stem.2020.03.004. [Abstract]
Griffin TM, Lories RJ. (2020) Cracking the code on the innate immune program in OA. Osteoarthritis and Cartilage. 28(5):529-531. DOI: 10.1016/j.joca.2020.03.013. [Abstract]
Andriacchi TP, Griffin TM, Loeser RF, Chu CR, Roos EM, Hawker GA, Erhart-Hledik JC, Fischer AG. (2020) Bridging Disciplines as a pathway to Finding New Solutions for Osteoarthritis a collaborative program presented at the 2019 Orthopaedic Research Society and the Osteoarthritis Research Society International. Osteoarthritis and Cartilage Open. Available online 17 Jan. https://doi.org/10.1016/j.ocarto.2020.100026. [Abstract]
Griffin TM, Batushansky A, Hudson J, Lopes EBP. (2020) Correlation Network Analysis Shows Divergent Effects of Long-term High Fat Diet and Exercise on Early-Stage Osteoarthritis Phenotypes in Mice. J Health and Sport Science (Special Issue on Exercise, Metabolism, Obesity, and Musculoskeletal Health). 9(2) 119-131. [Abstract]
Zhu S, Makosa D, Miller BF, Griffin TM. (2020) Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis. Connective Tissue Research. Jan;61(1):34-47 [Abstract]
Griffin TM, Friedman JE. (2020) How can parental obesity promote OA across generations? Nature Rev Rheumatology. Jan 16. 16(3):129-130. doi: 10.1038/s41584-020-0369-5. [Abstract]
2019
Griffin TM, Scanzello CR. (2019) Innate inflammation and synovial macrophages in osteoarthritis pathophysiology. Clin Exp Rheumatol. Sep-Oct;37 Suppl 120(5):57-63. Epub 2019 Oct 15. [Abstract]
Yang X, Brobst D, Chan WS, Tse MCL, Herlea-Pana O, Ahuja P, Bi X, Zaw AM, Kwong ZSW, Jia W-h, Zhang Z, Zhang N, Chow SKH, Cheung WH, Louie JCY, Griffin TM, Nong W, Hui JHL, Du G-h, Noh HL, Saengnipanthkul S, Chow BKC, Kim JK, Chi WL, and Chan CB. (2019) Muscle generated brain-derived neurotrophic factor is a sex-dimorphic myokine that controls metabolic flexibility. Science Signaling. 12(594), eaau1468 [Abstract]
Batushansky A, Lopes EBP, Zhu S, Humphries KM, Griffin TM. (2019) GC-MS Method for Metabolic Profiling of Mouse Femoral Head Articular Cartilage Reveals Distinct Effects of Tissue Culture and Development. Osteoarthritis and Cartilage. 27(9);1361-1371. [Abstract]
Batushansky A, Matsuzaki S, Newhardt MF, West MS, Griffin TM, and Humphries KM. (2019) GC-MS metabolic profiling reveals Fructose-2,6- bisphosphate regulates branched chain amino acid metabolism in the heart during fasting. Metabolomics. Jan 28;15(2):18. [Abstract]
Sivasami P, Poudel N, Munteanu M, Hudson J, Lovern P, Liu L, Griffin TM, and Hinsdale M. (2019) Adipose Tissue Loss and Lipodystrophy in Xylosyltransferase II Deficient Mice. Int J Obes (Lond). 43, 1783-1794. [Abstract]
Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz K, Matsuzaki S, Clafin D, Judge J, Bhaskaran S, Sataranatarajan K, Lopes E, Wronowski B, Kinter M, Humphries K, Griffin TM, Freeman WM, Richardson A, Herzog SB, Van Remmen H. (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia, Sarcopenia and Muscle. Apr;10(2):411-428. [Abstract]
Kalaitzoglou E, Barboza Prado Lopes E, Fu Y, Herron JC, Flaming JM, Donovan EL, Filiberti A, Griffin TM, and Humphrey MB. (2019) TLR4 promotes and DAP12 limits obesity-induced osteoarthritis in aged female mice. JBMR Plus. Apr;3(4):e10079. [Abstract]
2018
Donovan EL, Lopes EBP, Batushansky A, Kinter M, Griffin TM. (2018) Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice. Dis Model Mech. Aug 31;11(9). pii: dmm034827. [Abstract]
Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair B, Forbes B, Gispert S, Auburger G, Humphries K, Kinter M, Griffin TM, and Deepa S. (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep. Mar;19(3).pii: e45009 [Abstract]
Issa R, Boeving M, Kinter M, Griffin TM. (2018) Effect of biomechanical stress on endogenous antioxidant networks in bovine articular cartilage. J Orthop Res. Feb;36(2):760-769. [Abstract]
2017
He C, Medley SC, Kim J, Sun C, Kwon HR, Sakashita H, Pincu Y, Yao L, Eppard D, Dai B, Berry WL, Griffin TM, Olson LE. (2017) STAT1 modulates tissue wasting or overgrowth downstream from PDGFRβ. Genes Dev. Aug 15;31(16):1666-1678. [Epub ahead of print 2017 Sep 18]. [Abstract]
Kalaitzoglou E, Griffin TM, Humphrey MB. (2017) Innate Immune Responses and Osteoarthritis. Curr Rheumatol Rep. Aug;19(8):45. [Abstract]
Barboza, E; Hudson, J; Chang, WP; Kovats, S; Towner, RA; Silasi-Mansat, R; Lupu, F; Kent, C; Griffin, TM. (2017) Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precededs knee osteoarthritis in diet-induced obese mice. Arthritis Rheum. [Epub ahead of print Jan 31, 2017] [Abstract]
Berenbaum, F; Griffin, TM; Liu-Bryan, R. (2017) Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheum. Jan;69(1):9-21. [Abstract]
2016
June, RK; Liu-Bryan, R; Long, F; Griffin, TM. (2016) Emerging Role of Metabolic Signaling in Synovial Joint Remodeling and Osteoarthritis. J Orthop Res. Dec;34(12):2048-2058. [Abstract]
Fu, Y; Kinter, M; Hudson, J; Humphries, KM; Lane, RS; White, JR; Hakim, M; Pan, Y; Verdin, E; Griffin, TM. (2016) Aging Promotes SIRT3-dependent Cartilage SOD2 Acetylation and Osteoarthritis. Arthritis Rheum. Aug;68(8):1887-98. [Abstract] *F1000Prime recommended.
Griffin, TM; Huffman, KM. (2016) Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis? Arthritis Rheum. Jun;68(6):1330-3. PMID: 26749517 [PubMed – in process]. [Abstract]
Griffin, TM; Humphries, KM; Kinter, M; Lim, H-Y; Szweda, LI (2016) Nutrient Sensing and Utilization: Getting to the Heart of Metabolic Flexibility. Biochimie. May;124:74-83. PMCID: PMC4828282. [Abstract]
Fu, Y; Huebner, J; Kraus, V; Griffin, TM. (2016) Effect of aging on adipose tissue inflammation in the knee joints of F344BN rats. J Gerontol A Biol Sci Med Sci. Sep;71(9):1131-40. [Abstract]
2015
Wiley, MM; Muthukumar, V; Griffin, TM; and Griffin, CT (2015) SWI/SNF Chromatin-Remodeling Enzymes Brahma‐Related Gene 1 (BRG1) and Brahma (BRM) Are Dispensable in Multiple Models of Postnatal Angiogenesis But Are Required for Vascular Integrity in Infant Mice. J Am Heart Assoc. 4:e001972. doi: 10.1161/JAHA.115.001972. PMCID: PMC4579958. [Abstract] [Free PMC Article]
Lane, RS; Fu, Y; Matsuzaki, S; Kinter, M; Humphries, KM; Griffin, TM (2015) Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Therapy. Mar 10;17:54. doi: 10.1186/s13075-015-0566-9. [Abstract] [Free PMC Article] *Attained “Highly accessed” designation.
Fu Y, Griffin TM. Obesity, osteoarthritis and aging: the biomechanical links. In: Studies in mechanobiology, tissue engineering and biomaterials, v.16. Edited by Gefen A and Benayahu D. 2015. pp. 181-201. [Abstract]
2014
Zhao, Y; Ling, F; Griffin, TM; He, T; Towner, R; Ruan, H; Sun, X-H (2014) Up-regulation of the Sirt1 and PCG-1α genes in white adipose tissue of Id1 deficient mice: implications in the protection against diet and age-induced glucose intolerance. J Biol Chem., 289(42):29112-22. PMCID: PMC4200265. [Abstract][Free PMC Article]
Yao, L; Heuser-Baker, J; Herlea-Pana, O; Zhang, N; Szweda, LI; Griffin, TM; Barlic-Dicen, J (2014) Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity. FASEB J., 28(10):4534-50. PMCID: PMC4202106. [Abstract][Free PMC Article]
Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM. (2014) Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice. Osteoarthritis Cartilage. 22:1301-1309, 2014. PMCID: PMC4150746. [Abstract][Free PMC Article]
2013
Garteiser, P; Doblas, S; Towner, RA; Griffin, TM (2013) Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice. Metabolism, 62:1686–1695. PMCID: PMC3809152. [Abstract][Free PMC Article]
O’Conor, CJ; Griffin, TM; Liedtke, W; Guilak, F (2013) Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis., 72:300-304. PMCID: PMC3549299. [Abstract][Free PMC Article]
2012
Roach GC, Edke M, Griffin TM (2012) A novel mouse running wheel that senses individual limb forces: biomechanical validation and in vivo testing. J Appl Physiol. 113:627-635. PMCID: PMC4422345 [Abstract][Free PMC Article]
Issa RI, Griffin TM (2012) Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis. May 9;2. pii: 17470. PMCID: PMC3364606 [Abstract][Free PMC Article]
Griffin, TM (2012) Osteoarthritis. In: Encyclopedia of Exercise Medicine in Health and Disease. Editor: Frank. C. Mooren. Springer. [Abstract]
Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F (2012) Induction of osteoarthritis and metabolic inflammation by a very high fat diet in mice: Effects of short-term exercise. Arthritis Rheum. 64:443-453, 2012. PMCID: PMC3268860 [Abstract][Free PMC Article]
2010
Costello KE, Guilak F, Setton LA, Griffin TM (2010) Locomotor activity and gait in aged mice deficient for type IX collagen. J Appl Physiol. 109:211-218, 2010. [Abstract][Free PMC Article]
Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F (2010) Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther 12:R130. PMCID: PMC2945020. [Abstract][Free PMC Article] *Attained “Highly accessed” designation. Accompanying Editorial. van der Kraan, PM (2010) Osteoarthritis and a high-fat diet: the full ‘OA syndrome’ in a small animal model. Arthritis Res Ther. 12(4): 130. [Editorial Abstract]
2009
Griffin TM, Huebner JL, Kraus VB, Guilak F (2009) Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum 60:2935-2944. PMCID: PMC2829313 [Abstract][Free PMC Article] *The Arthritis Foundation named this paper as the second-most influential publication in the field for all of 2009. Accompanying Editorial. Sandell, LJ (2009) Obesity and osteoarthritis: is leptin the link? Arthritis Rheum, 60:2858-2860. [Editorial Abstract]
Allen, KD, Griffin, TM, Wetsel, WC, Rodriguiz, RM, Boyd LM, and Setton, LA (2009) Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum. 60(9):2684-93. PMCID: PMC2760314. [Abstract][Free PMC Article] Accompanying Editorial. Goldring, MB (2009) The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: a joint misadventure. Arthritis Rheum, 60:2550-2552. [Editorial Abstract]
2008
Griffin, TM and Guilak, F (2008) Why is obesity associated with osteoarthritis? Insights from mouse models of obesity. Biorheology. 45(3-4): 387-398. PMCID: PMC2748656. [Abstract][Free PMC Article]
Hanna, JB, Schmitt, D, and Griffin, TM (2008) The energetic cost of climbing in primates. Science. 320 (5878): 898. [Abstract] [Science Podcast]