We are excited to announce a new grant from the Veterans Administration. This research will help us to determine how intra-articular adipose tissue lipolysis mediates macrophage activation and joint inflammation in post-traumatic osteoarthritis. We will test the hypothesis that exercise reduces osteoarthritis pain through metabolic mechanisms that alter immune cell activation to reduce joint inflammation. This research may lead to new metabolic-based drug therapies that provide safer alternatives to opioids and non-steroidal anti-inflammatory drugs for reducing osteoarthritis pain.
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