The Griffin Lab hosted Dr. Eric Verdin on February 16th as the OMRF Research Forum speaker. Dr. Verdin recently took over as President and CEO of The Buck Institute for Research on Aging, and we were grateful that he fit us into his busy schedule. Dr. Verdin was a gracious guest. He shared many insights into sirtuins, acetylation, and aging, and he delivered an excellent seminar titled, “Metabolism, Epigenetics and Aging: A growing Nexus.”
Dr. Shouan Zhu joined the lab as a post-doctoral fellow in January of 2017. Shouan completed the first 3 years of his Ph.D. at the Center for Stem Cell & Tissue Engineering in Zhejiang University China under supervision of Dr. Hong Wei Ouyang. He earned a prestigious fellowship that allowed him to complete the 4th and 5th years of his Ph.D. research overseas. For this he joined the Department of Orthopedic Surgery at Johns Hopkins University, working on the mechanism of osteoarthritis pain under the supervision of Dr. Xu Cao. We’re excited to have Shouan join us, and we look forward to his exciting new discoveries!!
Our summer NARCH student, Hannah Taff, is back with us during her winter break from East Central University. Hannah is finishing analyzing knee samples from our collaborator, Ted Garland. She presented her initial findings this summer at UC Berkeley as a McNair Scholar. During the next two weeks she’ll finish analyzing changes in the cartilage and subchondral bone.
Two new co-authored review articles on metabolism and OA are now available online.
The first, published in Arthritis & Rheumatology, focuses on how the metabolic syndrome and related conditions contribute to OA pathogenesis. The article spans evidence from clinical studies and animal models to mechanistic evidence involving intra-articular fat tissue and cellular nutrient sensors (e.g., AMPK and Sirtuins). Read it here: Metabolic Regulation of Inflammation in Osteoarthritis
The second article was published in the Journal of Orthopaedic Research. It is based on topics that were discussed at a workshop presented at the 2016 Annual Meeting of the Orthopaedic Research Societyin Orlando, FL. Dr. Ron June and I co-organized the workshop, and we were thrilled to have Drs. Ru Liu-Bryan and Fanxing Long participate. If you missed the meeting, or want a recap, take a look at this article! Emerging Role of Metabolic Signaling in Synovial Joint Remodeling and Osteoarthritis
OMRF and OUHSC hosted the 24th Annual NIA-sponsored Summer Training Course in Experimental Aging Research this past week. It was a busy week for attendees, including our very own Elise Donovan, who presented her independent research proposal on proteostasis in osteoarthritis. Our colleagues Ron June and Adam Konopka also attended.
After a terrific graduate career in the lab, Dr. Yao Fu will be joining the Gaffney Lab at OMRF in July to start a new post-doctoral research position. We will miss you Yao, and we wish you the best of luck in the Gaffney Lab!!